June 13th, 2016

​For WRITTEN answer on Thursday, 9th June, 2016.

Details Supplied: Vertex pharmaceuticals
 
    
REPLY.
The HSE has statutory responsibility for decisions on pricing and reimbursement of medicines under the community drugs schemes, in accordance with the Health (Pricing and Supply of Medical Goods) Act 2013. Prior to deciding whether to reimburse a medicine, the HSE considers a range of statutory criteria, including clinical need, cost-effectiveness and the resources available. 
The decisions on which medicines are reimbursed by the taxpayer are made on objective, scientific and economic grounds by the HSE, on the advice of the National Centre for Pharmacoeconomics (NCPE). The NCPE conducts health technology assessments (HTAs) of pharmaceutical products for the HSE, and can make recommendations on reimbursement to assist the HSE in its decision-making process. The NCPE used a decision framework to systematically assess whether the drug  is cost-effective as a health intervention
I am informed that, following a request from the HSE, the NCPE carried out an assessment of the manufacturer's economic dossier submitted in March 2016 on the cost effectiveness of lumacaftor/ivacaftor (Orkambi). This dossier included details on all relevant costs and relevant cost offsets including hospitalisation, disease management costs, intravenous antibiotics, adverse events and any additional costs arising in patients not taking Orkambi.
The NCPE has completed its HTA and submitted it to the HSE. The NCPE determined, following an evaluation of the economic dossier, that the  manufacturer failed to demonstrate cost-effectiveness or value for money from using the drug. The NCPE have confirmed that  all relevant costs were included in the analysis.
A summary of the HTA has been published on the NCPE website and is available at: http://www.ncpe.ie/wp-content/uploads/2015/12/Website-summary-orkambi.pdf.
The HSE will now enter into negotiations with the manufacturer, to seek very significant price reductions.  The HSE will then consider the outcome of these negotiations, together with the NCPE recommendation, in making a final decision on reimbursement.